Ene-reductase (gene oyeRo2a) from Rhodococcus opacus 1CP

Enzyme Description

Extremophile
No
EC Number

Sequence

Length: 366 amino acids
MSVLFEPITFRGVTVPNRVWMAPMCQYSADVTGRDVGVPGDWHRTHLVTRAIGGAGLILTEATAVSPEGRISPADLGIWNDTQTEAFAEINRRIREFGAVPGIQLGHAGRKGSAHVPWRGGGSLDGDDRLSWQTVAPSAIGFGDHTPPAAATTADIRKVVADFAAAAERASRAGFKVVEIHAAHGYLLHQFLSPVSNHRTDEYGGSFAGRIRLLLEVVDAVRGVWPAELPVFVRVSATDWLSEEPGLDADSWTPDQTVSLVQALADLGVDLVDVSSGGVASARIPIGPGYQVPFARRIQNETTVPAAAVGLITEPEQAERIVESGEAVAVFLGRELLRDPYWPRKAALVLNAQVTPQIPAQYARAY
Anika Riedel et al. (2015) β€” Functional characterization and stability improvement of a 'thermophilic-like ' ene-reductase from Rhodococcus opacus 1CP
Frontiers in Microbiology  Β· doi:10.3389/fmicb.2015.01073 β†—  Β· Activity - Classical Stability - Incubation
22 measurements
Database ID
Sequence Annotation
Explicit - Provided
Protein Source
Recombinant, host bacterium Escherichia coli BL21 (DE3)

Experimental Data (22 measurements)

22 measurements β€” page 1 of 2
Property Assay Solvent Solvent Volume Aqueous Reference Measured Value Units Solution pH Temperature Substrate(s) Product(s) Cofactor(s) Shaking Comments
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 30% 100 7 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethyl Sulfoxide (DMSO) 40% 100 0 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethyl Sulfoxide (DMSO) 30% 100 50 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethyl Sulfoxide (DMSO) 20% 100 99 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethyl Sulfoxide (DMSO) 10% 100 101 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 10% 100 106 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 25% 100 27 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 20% 100 54 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 15% 100 83 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 10% 100 100 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Ethanol 5% 100 101 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethylformamide (DMF) 10% 100 12 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Dimethyl Sulfoxide (DMSO) 10% 100 101 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Acetonitrile 10% 100 36 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Acetone 10% 100 85 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Activity - Classical Activity measured by absorbance spectrophotometry (NADPH absorance measurement, 340 nm) in the presence of organic solvent Methanol 10% 100 85 % 25 mM phosphate buffer 7.1 25Β°C 1 mM Maleimide Succinimide 140 ΞΌM NADPH β€” Classical aqueous control (in %)
Stability - Incubation Activity after incubation (1 minute at 25Β°C), measured by absorbance spectrophotometry (NADPH absorbance measurement, 340 nm) in aqueous phase Ethanol 20% 100 97 % Incubation: 25 mM phosphate buffer, Assay: 25 mM phosphate buffer Incubation: 7.1, Assay: 7.1 Incubation: 25Β°C, Assay: 25Β°C 1 mM Maleimide Succinimide Assay: 140 ΞΌM NADPH β€” Non-incubated control (in %), assay in aqueous phase | Uncertainty about whether the assay was in aqueous phase or in the presence of organic solvent
Stability - Incubation Activity after incubation (3 minutes at 25Β°C), measured by absorbance spectrophotometry (NADPH absorbance measurement, 340 nm) in aqueous phase Ethanol 20% 100 86 % Incubation: 25 mM phosphate buffer, Assay: 25 mM phosphate buffer Incubation: 7.1, Assay: 7.1 Incubation: 25Β°C, Assay: 25Β°C 1 mM Maleimide Succinimide Assay: 140 ΞΌM NADPH β€” Non-incubated control (in %), assay in aqueous phase | Uncertainty about whether the assay was in aqueous phase or in the presence of organic solvent
Stability - Incubation Activity after incubation (5 minutes at 25Β°C), measured by absorbance spectrophotometry (NADPH absorbance measurement, 340 nm) in aqueous phase Ethanol 20% 100 61 % Incubation: 25 mM phosphate buffer, Assay: 25 mM phosphate buffer Incubation: 7.1, Assay: 7.1 Incubation: 25Β°C, Assay: 25Β°C 1 mM Maleimide Succinimide Assay: 140 ΞΌM NADPH β€” Non-incubated control (in %), assay in aqueous phase | Uncertainty about whether the assay was in aqueous phase or in the presence of organic solvent
Stability - Incubation Activity after incubation (10 minutes at 25Β°C), measured by absorbance spectrophotometry (NADPH absorbance measurement, 340 nm) in aqueous phase Ethanol 20% 100 15 % Incubation: 25 mM phosphate buffer, Assay: 25 mM phosphate buffer Incubation: 7.1, Assay: 7.1 Incubation: 25Β°C, Assay: 25Β°C 1 mM Maleimide Succinimide Assay: 140 ΞΌM NADPH β€” Non-incubated control (in %), assay in aqueous phase | Uncertainty about whether the assay was in aqueous phase or in the presence of organic solvent
β€Ή Prev
1 2

Visualization : Activity β€” Classical

One bar per measurement. Colour = solvent, shade = solvent volume.

Visualization : Stability β€” Incubation

One bar per measurement. Colour = solvent, shade = solvent volume.

Structure

Drag to rotate Β· Scroll to zoom Β· Right-click drag to pan Β· Powered by Mol*